Set as homepage  |  Add to Favorites
Navigation
Processing Machinery
Pharmaceutical Machinery
Packing Machine
Pharmaceutical Intermediates
Herb Extracts and Ingredients
Feeding Additives
AAC Plant Production Line
PreStressed Concrete Spun Pole Machinery
PreStressed Concrete Spun Pile Machinery
Fish Meal Production Line
Probiotic and Culture Production Equipment
PET Crushing Washing Recycling System
Probiotics
Boiler
Cement Production Line
Oil Refining Equipment
Link
 
AAC Machine
AAC Plant
Probiotic Machine
Products - Details
 
Keywords:
Products No. Hopeland 406
Name:Donepezil (EP,USP)
Picture
 
Introduction
Chemical Name: 2-[(1-benzyl-4-piperidyl) methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
CAS No.: 120014-06-4
Molecular formula: C24H29NO3
Molecular weight: 120014-06-4
Molecular structure:  
Applications
Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks. Donepezil is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.
Specifications
min98%
Appearance: Off white to yellowish crystalline powder
Shelf life
2 year when properly stored
Package
25kg/Drum
For more information please contact us: 85xianji@85xianji.com and icec0529@yahoo.com
Copyright © 2003-2013 Hopeland Chem-Tech Co., Ltd. All rights reserved.
Add.: Rm. B-1708, Taaffeite International Commerce Plaza, 4th Gaoxin Road, Xi'an City, Shaanxi Province, China
Postal Code: 710075
Cell phone: +86 135 7190 0119
Tel: +86 29 6296 0726
Fax: +86 29 6296 0725
Email: 85xianji@85xianji.com / icec0529@yahoo.com
Website: www.hopeland-cn.com


Web Stats: